Impact of Centralized Over-Read on Outcomes in Depression and Schizophrenia Trials

Research presented at the 2017 International Society for CNS Clinical Trials and Methodology (ISCTM) Fall Conference examined Central Review of two widely used efficacy measures administered in schizophrenia and depression trials, the Positive and Negative Syndrome Scale (PANSS) and Hamilton Depression Rating Scale (HAM-D), resulting in positive impact on individual item scores and total scale score for key study visits, improving interrater reliability and reducing rater drift.

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