MedAvante:  A Structurally Comprehensive Solution
to Reducing Bias and Variability in Clinical Trials

MedAvante's clinical methodology and operational expertise provides advanced signal detection solutions for diagnostic, screening, and symptom-severity assessments. By applying these extensive capabiolities, MedAvante overcomes the major threat to achieving signal detection: Issues with the trial assessments’ validity and reliability caused by biases and interviewer variability. 

The MedAvante structural solution:

• Appropriate patient enrollment according to protocol
• Accurate setting of baseline scores
• Highest interrater reliability due to continuous calibration

Traditional CNS trials suffer high rates of failure due to increasing rates of placebo response and inappropriate patient populations. 

An global cohort of study raters, even if comprised of high quality interviewers, can still result in poor reliability for the study as a whole, with an attendant negative effect on study power.  That is because each site is managed independently and the sites do not continuously calibrate with each other on what are fundamentally subjective measurements.

Most importantly, the highest risk factors for a successful trial are posed by bias, specifically enrollment and expectation biases that can nullify the beneficial impact of even the highest quality interviewing.