We improve signal detection in clinical trials

Chief Research Officer Mark Opler and his peers review the origin of the PANSS and its current use in global clinical trials. http://bit.ly/2rple1o

Post-hoc analysis of two vortioxetine trials in GAD patients compared those who were working or pursuing education with the full study population. http://bit.ly/2mPPrRr

Early stage trial of antisense oligonucleotide designed to keep cells from making mutant protein via a snippet of single-stranded DNA that halts an intermediate step in protein-making. http://bit.ly/2rdi1lf

Randomized clinical trials "don't give us good information on comparative performance between different drugs" as they typically only test one drug against placebo or another older drug says Fredrik Piehl of  Swedem's Karolinska Institute. http://wb.md/2Da2pDO

Idalopirdine fails to prove efficacy as Alzheimer’s treatment in Phase 3 . http://bit.ly/2DqIq1z

The rate of decline in in respiratory function,  measured by percentage predicted slow vital capacity (SVC) in patients with ALS, is a key indicator of the disease's clinical progression and associated with clinically meaningful events, including respiratory failure and death.  http://bit.ly/2lWFn9O

A triple receptor agonist originally invented by German researchers to treat type II diabetes "significantly reversed memory loss" in mice, could be used to treat Alzheimer's disease. http://bit.ly/2lF9YbA

Alzheimer’s Clinical Trial Consortium (ACTC) experts and infrastructure will support the design and conduct of trials across the full spectrum of Alzheimer’s and related dementias.  http://bit.ly/2BE6iAE

“For the first time a drug has lowered the level of the toxic disease-causing protein in the nervous system, and the drug was safe and well-tolerated,” said Prof Sarah Tabrizi, director of University College London’s Huntington’s Disease Centre.  http://bit.ly/2kjXi8K

Tiny "nanodiscs" composed of layers of lipids surrounded by a belt represent a very powerful platform to study intermediates formed in the process of protein aggregation. http://bit.ly/2iZ7xTc

Solutions for Sponsors and Contract Research Organizations (CROs)

We help sponsors and CROs improve reliability in clinical trials.

Virgil Platform

Use our eSource platform to maximize data quality, standardize assessments and improve signal detection.

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Independent Ratings

Our expert, calibrated raters remotely administer live assessments of subjects at sites to maximize study power and minimize bias and variability.

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Independent Review

Our global cohort of expert clinicians review assessment data and recordings to flag potential discrepancies and surface quality issues.

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Rater Qualification and Certification

Our clinical experts tailor training and certification via options ranging from face-to-face to totally virtual.

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Clinical Data Analytics

Our statisticians and clinical scientists help build data quality metrics that provide insight into how a study’s data are progressing.

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Solutions for Sites

Data capture happens every day at clinical trial sites. That’s why we rely on input from hundreds of raters, site coordinators, and PIs in evolving Virgil.

Virgil Tablet

Reduces administrative burden for clinicians and study coordinators.

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Virgil Portal

Enables raters, study coordinators and PIs to securely access the exact data each needs to streamline reviews, approvals and query resolution.

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Rater Training

Qualify for participation in studies with tailored, engaging and conveniently delivered training programs.

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What We Believe

MedAvante-ProPhase exists to help unlock new and better treatments through smarter, faster clinical trials.

We believe data will transform the way the world understands health and medicine, greatly improving the way potential treatments are tested.

Our mission is to apply deep scientific expertise to optimizing the quality of clinical trial outcome data. We will do this with cohesive, interoperable software and accurate, precise clinician services that work together to improve the collection, management and analysis of clinical study data.

Why MedAvante-ProPhase?

To improve the ability to detect a signal of efficacy in a clinical trial and reduce the risk of inconclusive results, drug developers, study teams and research clinicians need a capable and trusted global partner.

MedAvante-ProPhase is a clinical data sciences company providing science-driven, technology-enabled clinical measurement and signal detection solutions with a history of proven innovation.

Our clinical expertise and record of combining scientific innovation with digital capabilities is rooted in years of experience working with some of the most challenging of clinical trial outcomes – Central Nervous System (CNS) disorders.

The Virgil Investigative Study Platform, paired with our suite of clinician services, make MedAvante-ProPhase the most proficient and reliable global partner for improved signal detection and smarter, faster clinical trials.

Why Virgil?

Virgil was created by clinicians, for clinicians. Virgil addresses the real needs of raters and coordinators, and reduces process complexity and administrative burden for sites.

Virgil enables the full complement of electronic clinical outcome assessments (eCOA) including:

• Clinician-Reported Outcomes (eClinRO)

• Observer-Reported Outcomes (eObsRO)

• Patient-Reported Outcomes (ePRO)

Explore the Virgil Platform

Virgil amplifies the power of MedAvante-ProPhase clinician services as the digital platform delivering Independent Ratings and Independent Review with the same timely results and data quality, eliminating paper and increasing strategic options for a smarter trial.

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"The Virgil software and tablet is pretty amazing. It’s the most user/site friendly we have used for clinical trials and we have used several. The software mimics writing on paper extremely well, and we appreciate that there wasn’t any skimping in the processor speed. The Virgil tablet has gained some big fans at our site."

— Principal Investigator, USA

"The industry is hungry for innovation. And they’re hungry for innovation because the current models are struggling."

— Senior executive, large pharma

"Our team finds the tablets operating on the Virgil system very user-friendly very easy to get used to and really straight forward to work with. It is fast and properly responsive to our inputs, stylus use is similar to using a normal pen and paper set-up. All in all, the Virgil system is our favourite system to work with!"

— Principal Investigator, EU

"Losing patient data can be tragic. I look very carefully at data loss rates because I want them to be 0.01% or 0%. I cannot afford to lose data. The loss rates are a way that I differentiate one provider from another."

— Senior executive, biotech

"The Virgil tablet and its well-designed digital scales improve our ability to administer quality assessment by being easy-to-use and helpful to our raters. We like the way recordings are collected and appreciate the convenience of handling them with no additional steps for our team to perform… We have had a very good experience with the Virgil platform and we recommend its use to any clinical trial sponsor."

— Principal Investigator, USA

Our approach

We design with a clinician’s brain and a startup’s heart. Created by clinicians for clinicians, Virgil provides built-in clinical guidance to help standardize assessments and increase the quality of trial results.

How we help

We provide clinicians and researchers with the tools, data-driven insights, and guidance they need to get their work done more easily and efficiently.

Our services, technologies, and clinical guidance help bring drug therapies to market with smarter, faster, more adaptive clinical trials.

6000+ hours of R&D

2M+ pages

MedAvante, for clinicians by clinicians.

How we help

We provide clinicians and researchers the tools, data-driven insights and guidance they need to get their work done more easily and efficiently.

Get a Virgil Demo

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Since 2005

MedAvante, for clinicians by clinicians